Differential scanning calorimetry (DSC) is a robust and powerful physical method for characterizing the thermal stability of proteins. During the life history of a commercial therapeutic protein product, DSC analysis is uniquely valuable from early discovery research to commercial product management. Areas in which DSC is used include: comparing stability of potential drug candidates; conducting preformulation and formulation screening studies; biophysical characterization of drug product for regulatory filings; comparability studies after a manufacturing change; and comparing a biosimilar to an innovator drug product. DSC analysis of a protein also can provide insightful data in investigations of the roles of specific domains in the instability and aggregation of multidomain proteins.
In this webinar, some examples of these applications will be described. In addition, results from studies on the effects of heating rate will presented, which demonstrate that faster heating results in both increased sample throughput and increased method sensitivity. Finally, data will be presented from a recent biophysical comparison of antibody drug conjugates to the parent antibody. These results documented that important differences in thermal stability could readily be resolved and quantified with DSC; whereas during heating studies with various spectroscopic techniques no differences were discernable.
More information Why attend?
The audience will learn about the value that DSC and the assessment of thermal stability bring throughout the development of a biological drug product – whether an innovator molecule or a biosimilar. Real data will be shown from products currently in development. This presentation will also explain the positioning of DSC among other similar and competitive types of analysis, and provide information on the utilities of various technologies during development and manufacture. Additional information will be provided on the real value provided by the latest DSC system on the market – the MicroCal PEAQ-DSC.
Who should attend?
Anyone involved in biological drug or biosimilar development or manufacture, throughout the pipeline, who is interested in understanding the value of thermal stability assessment. Also those who would like to know about some of the practical advantages of the new MicroCal PEAQ-DSC systems.
What will you learn?
This presentation will follow development challenges throughout a biological drug product’s life cycle: from candidate selection, through early and late stage formulation development, through to assessing changes in manufacturing processes and biosimilarity. The audience will see real data from industrial biosimilarity assessments and understand the value of characterizing their product’s thermal stability
Global demand for cement continues to increase and analysts project that the industry will maintain a healthy growth rate well into 2020. This positive outlook translates into mounting pressures on the manufacturers to increase throughput of new and existing plants while at the same time striving to reduce the environmental impact of cement manufacture though process optimization and use of clinker substitutes. This presentation will review the importance of elemental and mineralogical analysis and the value of precise analytical data to plant operations. We will also discuss the importance of cement fineness and how precision and timeliness aspects of particle size analysis are related to production control and efforts to optimize grinding and reduce energy consumption.
More information Who should attend?
Plant Managers, Process Engineers, Laboratory Managers, QA/QC technicians.
What will you learn?
Recognize the importance of implementing robust analytical methods for elemental, mineralogical and fineness characterization of cement and how the data can be used to improve and optimize various aspects of cement production.
Learn about the value and synergies between XRF, XRD and PSD analyses in cement manufacture and review the economic impact advanced analytical tools can have on plant performance.
Many industrial adsorptive separation processes are dealing with vapors and/or adsorption of components with very low concentrations. Many ongoing phenomena can only be observed and quantified in gas flow experiments. For low concentrations, Co-adsorption effects become highly important. The measurement of breakthrough curves allows to see displacement phenomena and to evaluate the technically usable sorption capacity under process-near conditions. The adsorption of water and organic vapors, as well as vapor mixtures and also the removal of CO2 from air have been investigated with the dynaSorb BT among other examples.
Değerli Bilim İnsanları, Kamu ve Özel Sektörün Uzman ve Temsilcileri,
Kimyagerler Derneği ve Atatürk Üniversitesi tarafından düzenlenecek olan 5. İlaç Kimyası: İlaç Etkin Maddesi Tasarımı, Sentezi, Üretimi ve Standardizasyonu Kongresi’nde biz de yerimizi aldık. Uluslararası katılımlı bu kongreye göstereceğiniz ilgiye şimdiden teşekkür ediyor, 30 Mart-2 Nisan 2017 tarihleri arasında 15 numaralı standda uzman satış mühendislerimiz ile sizleri bekliyoruz.
Mart 30 (Perşembe) 9:00 am - Nisan 2 (Pazar) 5:00 pm